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Watch Carefully (2)pentobarbital will decrease the extent or outcome of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Robust CYP3A4 inducers might decrease suvorexant efficacy; if elevated suvorexant dose required, never exceed 20 mg/working daypentobarbital will lessen the extent or impact of dapso